Endocrine Abstracts

The patients with polycystic ovary syndrome (PCOS) are at increased risk for insulin resistance, central obesity, dyslipidemia and hypertension. In our study, we aimed to detect whether women with PCOS who had normal OGTT results have had insulin resistance. Moreover we investigated the association of probable insulin resistance with cardiovascular risk indicators such as hs-CRP and carotid intima media thickness (CIMT).In total, 34 untreated PCOS patien...

Obesity is due to the combined effects of genetic, environmental, lifestyle and the interactions of these factors. Leptin (LEP) is an adipocyte-derived hormone that acts to reduce food intake and increase energy expenditure by binding and activating its specific receptor in the hypothalamus. In humans, LEP and LEPR have been mapped to 7q31.3 and lp31, respectively. The LEP and LEPR genes have been investigated in the search for gene variants potentially related to the pathophy...

Overt hypothyroidism is associated with an increased risk for cardiovascular disease. We aimed in this study, to assess the changes in renal function, serum lipids, vitamin B12, folate and homocysteine levels before and after treatment in hypothyroid patients.Fifty-four (male/female;7/47) hypothyroid patients enrolled to study. We measured homocysteine(tHcy), total cholesterol(TC), triglyceride(TG), HDL-cholesterol (HDL-C), creatinine, folic acid, and vi...